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Review
. 2010 Sep-Oct;86(5):995-9.
doi: 10.1111/j.1751-1097.2010.00767.x.

Differential signaling circuits in regulation of ultraviolet C light-induced early- and late-phase activation of NF-κB

Shiyong Wu  1 , Lingying Tong
Affiliations
Review

Differential signaling circuits in regulation of ultraviolet C light-induced early- and late-phase activation of NF-κB

Shiyong Wu et al. Photochem Photobiol. 2010 Sep-Oct.

Abstract

Ultraviolet C light (UVC) induces nuclear factor-kappa B (NF-κB) activation via a complex network. In the early phase (4-12 h) of irradiation, NF-κB activation is accompanied with IκBα reduction via a translation inhibition pathway. In the late phase of UVC-induced NF-κB activation (16-24 h), the IκBα depletion is a combined result of regulation at both transcriptional and translational levels. However, the NF-κB activation appears to be independent of the level of IκBα. In this review, we will discuss the multiple signaling circuits that regulate NF-κB activation during the early and late phases of UVC irradiation.

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Figures

Figure 1
Figure 1
Signaling circuit that regulates UVC-induced early-phase activation of NF-κB.
Figure 2
Figure 2
Signaling circuit that regulates UVC-induced late-phase activation of NF-κB.
See this image and copyright information in PMC

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