Underpowered trials in critical care medicine: how to deal with them?
- PMID: 20553632
- PMCID: PMC2911724
- DOI: 10.1186/cc9021
Underpowered trials in critical care medicine: how to deal with them?
Comment on
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Delta inflation: a bias in the design of randomized controlled trials in critical care medicine.Crit Care. 2010;14(2):R77. doi: 10.1186/cc8990. Epub 2010 Apr 29. Crit Care. 2010. PMID: 20429873 Free PMC article.
References
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- Roozenbeek B, Maas AI, Lingsma HF, Butcher I, Lu J, Marmarou A, McHugh GS, Weir J, Murray GD, Steyerberg EW. Baseline characteristics and statistical power in randomized controlled trials: selection, prognostic targeting, or covariate adjustment? Crit Care Med. 2009;37:2683–2690. doi: 10.1097/CCM.0b013e3181ab85ec. - DOI - PubMed
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- Hernández AV, Steyerberg EW, Butcher I, Mushkudiani N, Taylor GS, Murray GD, Marmarou A, Choi SC, Lu J, Habbema JD, Maas AI. Adjustment for strong predictors of outcome in traumatic brain injury trials: 25% reduction in sample size requirements in the IMPACT study. J Neurotrauma. 2006;23:1295–1303. doi: 10.1089/neu.2006.23.1295. - DOI - PubMed
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