doi: 10.1016/j.ejmech.2010.05.043.
Epub 2010 May 26.
Synthesis and evaluation of graveoline and graveolinine derivatives with potent anti-angiogenesis activities
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- PMID: 20554355
- DOI: 10.1016/j.ejmech.2010.05.043
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Synthesis and evaluation of graveoline and graveolinine derivatives with potent anti-angiogenesis activities
Eur J Med Chem.
2010 Sep.
Abstract
A series of graveoline and graveolinine derivatives were synthesized. The biological results showed that most of graveoline derivatives possessed higher cytotoxicity and better inhibitive effect against the adhesion and migration of human umbilical vein endothelial cell (HUVEC) than graveolinine derivatives. Among these compounds, 8d was the most potent agents that also showed significant anti-angiogenesis activities in chick embryo chorioallantoic membrane (CAM) assay.
2010 Elsevier Masson SAS. All rights reserved.
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