Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Jul;10(7):489-503.
doi: 10.1038/nrc2875. Epub 2010 Jun 17.

Sphingosine 1-phosphate and cancer

Nigel J Pyne  1 , Susan Pyne
Affiliations
Review

Sphingosine 1-phosphate and cancer

Nigel J Pyne et al. Nat Rev Cancer. 2010 Jul.

Abstract

There is substantial evidence that sphingosine 1-phosphate (S1P) is involved in cancer. S1P regulates processes such as inflammation, which can drive tumorigenesis; neovascularization, which provides cancer cells with nutrients and oxygen; and cell growth and survival. This occurs at multiple levels and involves S1P receptors, sphingosine kinases, S1P phosphatases and S1P lyase. This Review summarizes current research findings and examines the potential for new therapeutics designed to alter S1P signalling and function in cancer.

PubMed Disclaimer

References

    1. Cancer Res. 2007 Nov 1;67(21):10466-74 - PubMed
    1. J Soc Gynecol Investig. 2001 Jan-Feb;8(1):1-13 - PubMed
    1. Anticancer Res. 2003 Jul-Aug;23(4):3183-93 - PubMed
    1. Breast Cancer Res Treat. 2008 Nov;112(1):41-52 - PubMed
    1. J Neurooncol. 2010 May;98(1):41-7 - PubMed

Publication types

LinkOut - more resources