Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991:19 Suppl 3:S167-9.
doi: 10.1007/BF01643691.

MICs of ciprofloxacin and trimethoprim for Escherichia coli: influence of pH, inoculum size and various body fluids

J Aagaard  1 , T Gasser, P Rhodes, P O Madsen
Affiliations

MICs of ciprofloxacin and trimethoprim for Escherichia coli: influence of pH, inoculum size and various body fluids

J Aagaard et al. Infection. 1991.

Abstract

The influence of pH, inoculum size, human urine and prostatic extract on the MICs of ciprofloxacin and trimethoprim for Escherichia coli was investigated. There was no influence by the bacterial inoculum size within wide ranges on either drug. An increase in pH had a variable influence on the MICs of trimethoprim for E. coli but lowered those of ciprofloxacin considerably. Human prostatic extract increased the trimethoprim MIC for E. coli but lowered those of ciprofloxacin as compared to Mueller Hinton broth. Human urine increased the MICs of both drugs for E. coli.

PubMed Disclaimer

References

    1. J Urol. 1978 Dec;120(6):695-8 - PubMed
    1. Antimicrob Agents Chemother. 1985 Apr;27(4):449-51 - PubMed
    1. J Urol. 1970 Feb;103(2):187-94 - PubMed
    1. Antimicrob Agents Chemother. 1983 Nov;24(5):754-63 - PubMed

Publication types

MeSH terms

LinkOut - more resources