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Review
. 2010 Jun;130(2):166-71.
doi: 10.1111/j.1365-2567.2010.03289.x.

Multi-tasking of helper T cells

Yisong Y Wan  1
Affiliations
Review

Multi-tasking of helper T cells

Yisong Y Wan. Immunology. 2010 Jun.

Abstract

CD4 T helper cells (Th) are critical in combating pathogens and maintaining immune homeostasis. Since the establishment of the Th1-Th2 paradigm in the 1980s, many types of specialized Th cells, including Th1, Th2, Th17, Th9, follicular helper T and regulatory T, have been identified. We have become accustomed to the idea that different Th cells are 'committed' to their paths but recent emerging evidence suggests that under certain conditions, seemingly committed Th cells possess plasticity and may convert into other types of effector cells. In this review, we will first introduce the major sub-types of Th cells that are involved in immune regulation. Then, we will describe in detail the inter-convertibility of Th cells among different sub-types under in vitro and in vivo conditions. Finally, we will discuss our current understanding of the underlying mechanisms on how a particular type of Th cells may convert into other types of Th cells.

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Figures

Figure 1
Figure 1
Inter-conversion among T helper (Th) cell subsets. Under the influence of cytokines, regulatory T (Treg) cells convert into other types of Th cells in vitro (connected by blue lines). In addition, through yet-to-be-defined mechanisms, Th1, Th2, Th17, follicular helper T (Tfh) and Treg cells with no (Foxp3Neg) or reduced (Foxp3Low) Foxp3 expression can convert into other Th cells in vivo (connected by green lines). IFN-γ, interferon-γ; IL, interleukin; ROR, retinoic acid-related orphan receptors.
See this image and copyright information in PMC

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