Tarenflurbil: mechanisms and myths
- PMID: 20558395
- PMCID: PMC3526376
- DOI: 10.1001/archneurol.2010.94
Tarenflurbil: mechanisms and myths
Comment on
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Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial.JAMA. 2009 Dec 16;302(23):2557-64. doi: 10.1001/jama.2009.1866. JAMA. 2009. PMID: 20009055 Free PMC article. Clinical Trial.
References
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- Wilcock GK, Black SE, Hendrix SB, Zavitz KH, Swabb EA, Laughlin MA Tarenflurbil Phase II Study Investigators. Efficacy and safety of tarenflurbil in mild to moderate Alzheimer’s disease: a randomised phase II trial. Lancet Neurol. 2008;7(6):483–493. - PubMed
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- Galasko DR, Graff-Radford N, May S, et al. Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals. Alzheimer Dis Assoc Disord. 2007;21(4):292–299. - PubMed
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- Martone RL, Zhou H, Atchison K, et al. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer’s disease. J Pharmacol Exp Ther. 2009;331(2):598–608. - PubMed
