Phenotypic and evolutionary plasticity of body composition in rats selectively bred for high endurance capacity
- PMID: 20558760
- PMCID: PMC2944643
- DOI: 10.1152/japplphysiol.01026.2009
Phenotypic and evolutionary plasticity of body composition in rats selectively bred for high endurance capacity
Abstract
We investigated the effects of genetic selection and prolonged wheel access (8 wk) on food consumption and body composition in lines of rats selected for high and low intrinsic (untrained) endurance running capacity (HCR and LCR, respectively) to test the generality of phenotypic correlations between physical activity levels, aerobic capacity, and body composition. HCR rats ran more minutes per day on activity wheels than LCR rats, supporting the hypothesis that voluntary activity and physiological capacity are genetically correlated (self-induced adaptive plasticity). Both treatments (selection and wheel access) significantly affected food consumption. HCR rats consumed and digested more food than LCR rats. Access to running wheels did not result in changes in overall body mass, but lean body mass increased and percent body fat decreased in both lines. Selection for high endurance capacity resulted in hypertrophy of the heart and kidneys and decreased long intestine length. We found significant phenotypic flexibility in a number of organ masses after wheel running. Specifically, access to running wheels resulted in hypertrophy of the heart, liver, kidney, stomach, and small and large intestines in LCR and HCR rats. The selected line×wheel access interaction was significantly greater in HCR rats in relative mass for the heart and lung. Compared with LCR rats, HCR rats fortify wheel running with increased food consumption along with greater hypertrophy of key organs for O2 transport.
Similar articles
-
Effects of intrinsic aerobic capacity and ovariectomy on voluntary wheel running and nucleus accumbens dopamine receptor gene expression.Physiol Behav. 2016 Oct 1;164(Pt A):383-9. doi: 10.1016/j.physbeh.2016.06.006. Epub 2016 Jun 11. Physiol Behav. 2016. PMID: 27297873 Free PMC article.
-
Maternal exposure to Western diet affects adult body composition and voluntary wheel running in a genotype-specific manner in mice.Physiol Behav. 2017 Oct 1;179:235-245. doi: 10.1016/j.physbeh.2017.06.008. Epub 2017 Jun 15. Physiol Behav. 2017. PMID: 28625550 Free PMC article.
-
Selection for aerobic capacity affects corticosterone, monoamines and wheel-running activity.Physiol Behav. 2008 Mar 18;93(4-5):1044-54. doi: 10.1016/j.physbeh.2008.01.013. Epub 2008 Jan 26. Physiol Behav. 2008. PMID: 18304593 Free PMC article.
-
Female rats selectively bred for high intrinsic aerobic fitness are protected from ovariectomy-associated metabolic dysfunction.Am J Physiol Regul Integr Comp Physiol. 2015 Mar 15;308(6):R530-42. doi: 10.1152/ajpregu.00401.2014. Epub 2015 Jan 21. Am J Physiol Regul Integr Comp Physiol. 2015. PMID: 25608751 Free PMC article.
-
Systemic oxygen transport in rats artificially selected for running endurance.Respir Physiol Neurobiol. 2006 Apr 28;151(2-3):141-50. doi: 10.1016/j.resp.2005.09.012. Epub 2005 Dec 15. Respir Physiol Neurobiol. 2006. PMID: 16344008 Review.
Cited by
-
Enhanced cardiac protein glycosylation (O-GlcNAc) of selected mitochondrial proteins in rats artificially selected for low running capacity.Physiol Genomics. 2013 Jan 7;45(1):17-25. doi: 10.1152/physiolgenomics.00111.2012. Epub 2012 Nov 6. Physiol Genomics. 2013. PMID: 23132757 Free PMC article.
-
Spontaneous physical activity protects against fat mass gain.Int J Obes (Lond). 2012 Apr;36(4):603-13. doi: 10.1038/ijo.2011.108. Epub 2011 May 24. Int J Obes (Lond). 2012. PMID: 21610695 Free PMC article.
-
Resveratrol enhances exercise training responses in rats selectively bred for high running performance.Food Chem Toxicol. 2013 Nov;61:53-9. doi: 10.1016/j.fct.2013.01.051. Epub 2013 Feb 17. Food Chem Toxicol. 2013. PMID: 23422033 Free PMC article.
-
Physiological and Biochemical Effects of Intrinsically High and Low Exercise Capacities Through Multiomics Approaches.Front Physiol. 2019 Sep 18;10:1201. doi: 10.3389/fphys.2019.01201. eCollection 2019. Front Physiol. 2019. PMID: 31620020 Free PMC article.
-
Selectively breeding for high voluntary physical activity in female mice does not bestow inherent characteristics that resemble eccentric remodeling of the heart, but the mini-muscle phenotype does.Sports Med Health Sci. 2023 Jul 7;5(3):205-212. doi: 10.1016/j.smhs.2023.07.003. eCollection 2023 Sep. Sports Med Health Sci. 2023. PMID: 37753423 Free PMC article.
References
-
- Allen DL, Harrison BC, Maass A, Bell ML, Byrnes WC, Leinwand LA. Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouse. J Appl Physiol 90: 1900–1908, 2001 - PubMed
-
- Bouchard C, An P, Rice T, Skinner JS, Wilmore JH, Gagnon J, Perusse L, Leon AS, Rao DC. Familial aggregation of V̇o2max response to exercise training: results from the HERITAGE Family Study. J Appl Physiol 87: 1003–1008, 1999 - PubMed
-
- Chappell MA, Garland T, Robertson GF, Saltzman W. Relationships among running performance, aerobic physiology and organ mass in male Mongolian gerbils. J Exp Biol 210: 4179–4197, 2007 - PubMed
-
- De Bono JP, Adlam D, Paterson DJ, Channon KM. Novel quantitative phenotypes of exercise training in mouse models. Am J Physiol Regul Integr Comp Physiol 290: R926–R934, 2006 - PubMed
-
- De Moor MHM, Liu YJ, Boomsma DI, Li J, Hamilton JJ, Hottenga JJ, Levy S, Liu XG, Pei YF, Posthuma D, Recker RR, Sullivan PF, Wang L, Willemsen G, Yan H, De Geus EJC, Deng HW. Genome-wide association study of exercise behavior in Dutch and American adults. Med Sci Sports Exerc 41: 1887–1895, 2009 - PMC - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Miscellaneous