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. 2010;70(2):92-6.
doi: 10.1159/000313844. Epub 2010 Jun 17.

Pilot study on schizophrenia in Sardinia

Jurg Ott  1 , Fabio Macciardi, Yuanyuan Shen, Mauro G Carta, Andrea Murru, Riccardo Triunfo, Renato Robledo, Antoniettina Rinaldi, Licinio Contu, Marcello Siniscalco
Affiliations

Pilot study on schizophrenia in Sardinia

Jurg Ott et al. Hum Hered. 2010.

Abstract

Objective: Based on a small sample of cases with schizophrenia and control individuals from an isolated population, a genome-wide association study was undertaken to find variants conferring susceptibility to this disease.

Methods: Standard association tests were employed, followed by newer multilocus association methods (genotype patterns).

Results: Individually, no variant produced a significant result. However, the best two variants (rs1360382 on chromosome 9 and rs1303 on chromosome 14) showed significantly different genotype pattern distributions between patients and control individuals. The risk genotype pattern AA-TT is highly predictive of schizophrenia, with estimated sensitivity and specificity of 1 and 0.96, respectively.

Conclusions: These findings support the hypothesis that schizophrenia is partly due to multiple genetic variants, each with a relatively small effect.

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Figures

Fig. 1
Fig. 1
Histogram of p values for 36 SNPs selected because they were previously shown to be associated with schizophrenia.
See this image and copyright information in PMC

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