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Review
. 2009 Mar;2(1):63-70.
doi: 10.1007/s12265-008-9072-7. Epub 2008 Oct 17.

The biological basis of thrombosis and bleeding in patients with ventricular assist devices

Ranjit John  1 , Sangjin Lee
Affiliations
Review

The biological basis of thrombosis and bleeding in patients with ventricular assist devices

Ranjit John et al. J Cardiovasc Transl Res. 2009 Mar.

Abstract

The clinical success of left ventricular assist devices (LVADs) has been tempered by significant hemorrhagic and thromboembolic complications. In the case of LVADs, where the biomaterial is in direct contact with the blood circulation, significant changes in systemic immunologic and thrombostatic functions have been well documented. Although further investigation is warranted, significant advances have been made in both cellular biology and LVAD technology to better understand the delicate balance between the procoagulant milieu predisposing to thrombosis and the risks of both surgical and non-surgical bleeding.

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