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. 1991 Jul;33(1):1-6.
doi: 10.1016/0165-5728(91)90028-6.

Modulation of specific immunity by ventral hippocampal formation in albino rats

R S Devi  1 , A Namasivayam
Affiliations

Modulation of specific immunity by ventral hippocampal formation in albino rats

R S Devi et al. J Neuroimmunol. 1991 Jul.

Abstract

Rats with bilateral electrolytic ventral hippocampal formation (VHF) lesion show a significantly (p less than 0.001) enhanced migration of leucocytes in the presence of antigen. Immunization in these animals enhances (p less than 0.001) the leucocyte migration and presents a significant decrease in footpad thickness. Antibody titre (p less than 0.001) and plaque-forming cells (p less than 0.02) also show a significant decrease when compared with sham-lesion-immunized animals and control-immunized animals. These data indicate the influence of VHF in modulating the specific immunity.

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