Assemble: an interactive graphical tool to analyze and build RNA architectures at the 2D and 3D levels
- PMID: 20562414
- PMCID: PMC2916716
- DOI: 10.1093/bioinformatics/btq321
Assemble: an interactive graphical tool to analyze and build RNA architectures at the 2D and 3D levels
Abstract
Summary: Assemble is an intuitive graphical interface to analyze, manipulate and build complex 3D RNA architectures. It provides several advanced and unique features within the framework of a semi-automated modeling process that can be performed by homology and ab initio with or without electron density maps. Those include the interactive editing of a secondary structure and a searchable, embedded library of annotated tertiary structures. Assemble helps users with performing recurrent and otherwise tedious tasks in structural RNA research.
Availability and implementation: Assemble is released under an open-source license (MIT license) and is freely available at http://bioinformatics.org/assemble. It is implemented in the Java language and runs on MacOSX, Linux and Windows operating systems.
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References
-
- Do CB, et al. CONTRAfold: RNA secondary structure prediction without physics-based models. Bioinformatics. 2006;22:e90–e98. - PubMed
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