The genetic components of idiopathic nephrolithiasis
- PMID: 20563734
- DOI: 10.1007/s00467-010-1562-6
The genetic components of idiopathic nephrolithiasis
Abstract
Nephrolithiasis is a cause of significant morbidity and medical care expenses worldwide. Its prevalence has increased steadily during the last three decades among both adults and children. This trend suggests that changing environmental factors play a significant role in the risk of developing kidney stones although, conversely, there are many indications that genes play an important role in this condition as well. A limited number of monogenic forms have been identified, but the majority of nephrolithiasis cases are the result of complex, multi-factorial interactions between genetic inheritance and environmental exposure. Scientific evidence indicates that inheritance accounts for about half of the risk of common forms, making these forms suitable for investigation by genetic analysis. Here, we review the numerous studies that have been conducted to establish the role of genes in determining the risk of nephrolithiasis, the differential contribution of genes to this risk, and the confounding influence that environmental variables have on genetic studies.
Similar articles
-
A narrative review of monogenic disorders causing nephrolithiasis and chronic kidney disease.Nephrology (Carlton). 2024 Dec;29(12):781-790. doi: 10.1111/nep.14373. Epub 2024 Nov 5. Nephrology (Carlton). 2024. PMID: 39497582 Review.
-
Family history influences clinical course of idiopathic calcium nephrolithiasis: case-control study of a large cohort of Italian patients.J Nephrol. 2016 Oct;29(5):645-51. doi: 10.1007/s40620-015-0225-x. Epub 2015 Aug 22. J Nephrol. 2016. PMID: 26296722
-
Idiopathic Osteoporosis and Nephrolithiasis: Two Sides of the Same Coin?Int J Mol Sci. 2020 Oct 31;21(21):8183. doi: 10.3390/ijms21218183. Int J Mol Sci. 2020. PMID: 33142950 Free PMC article. Review.
-
Personalized Intervention in Monogenic Stone Formers.J Urol. 2018 Mar;199(3):623-632. doi: 10.1016/j.juro.2017.09.143. Epub 2017 Oct 20. J Urol. 2018. PMID: 29061541 Free PMC article. Review.
-
Heritability of dietary traits that contribute to nephrolithiasis in a cohort of adult sibships.J Nephrol. 2016 Feb;29(1):45-51. doi: 10.1007/s40620-015-0204-2. Epub 2015 May 12. J Nephrol. 2016. PMID: 25963767 Free PMC article.
Cited by
-
Approach to the Adult Kidney Stone Former.Clin Rev Bone Miner Metab. 2012 Mar;10(1):38-49. doi: 10.1007/s12018-011-9111-9. Clin Rev Bone Miner Metab. 2012. PMID: 22654574 Free PMC article.
-
Protective Effects of Total Flavonoids from Lysimachia christinae on Calcium Oxalate-Induced Oxidative Stress in a Renal Cell Line and Renal Tissue.Evid Based Complement Alternat Med. 2021 Sep 20;2021:6667902. doi: 10.1155/2021/6667902. eCollection 2021. Evid Based Complement Alternat Med. 2021. PMID: 34603474 Free PMC article.
-
16S rRNA gene sequencing reveals altered composition of gut microbiota in individuals with kidney stones.Urolithiasis. 2018 Nov;46(6):503-514. doi: 10.1007/s00240-018-1037-y. Epub 2018 Jan 20. Urolithiasis. 2018. PMID: 29353409
-
Frequency of rare allelic variation in candidate genes among individuals with low and high urinary calcium excretion.PLoS One. 2013 Aug 26;8(8):e71885. doi: 10.1371/journal.pone.0071885. eCollection 2013. PLoS One. 2013. PMID: 23991001 Free PMC article.
-
Correlation of Parathormone and the Serum Values of Acidum Uricum with Calcium Nephrolithiasis Examined by Three Different Methods of Diagnostics.Acta Inform Med. 2015 Jun;23(3):132-4. doi: 10.5455/aim.2015.23.132-134. Epub 2015 May 25. Acta Inform Med. 2015. PMID: 26236076 Free PMC article.
References
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical