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Comparative Study
. 2010 Jun;26(3):273-6.
doi: 10.1089/jop.2009.0111.

Handling test of eye drop dispenser--comparison of unit-dose pipettes with conventional eye drop bottles

Minna Parkkari  1 , Terho Latvala, Auli Ropo
Affiliations
Comparative Study

Handling test of eye drop dispenser--comparison of unit-dose pipettes with conventional eye drop bottles

Minna Parkkari et al. J Ocul Pharmacol Ther. 2010 Jun.

Abstract

Purpose: The aims of this study were to investigate how elderly people handle single-use eye drop dispensers (unit-dose pipettes) and to compare the performance with conventional eye drop bottles.

Methods: In this open-label study, the handling of unit-dose pipettes and conventional eye drop bottles was compared in 41 elderly people who had little or no prior regular use of eye drop dispensers. The participants tested both types of dispenser once, and the following 7 variables were studied: ease/difficulty of opening the dispenser; influence of the size for handling of the dispenser; influence of the shape for handling of the dispenser; observation of the contents in the dispenser; the feeling of the dispenser in the hand; ease/difficulty of drop instillation on the eye from the dispenser; and overall performance of the eye drop dispenser. The dispensers contained isotonic saline, and a visual analog scale was used for assessment of each of the above variables.

Results: The mean age of the participants was 73 years. A statistically significant difference in favor of the unit-dose pipettes was found with respect to observation of the contents in the dispenser, ease of administration, and the overall performance. Women regarded the unit-dose pipettes generally better than the bottles, but such a difference was not seen in men.

Conclusions: The study participants managed the unit-dose pipettes at least as well as the conventional eye drop bottles. If anything, the unit-dose pipettes appeared to be easier to use.

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Figures

FIG. 1.
FIG. 1.
Types of dispensers used in the study.
FIG. 2.
FIG. 2.
Differences in the results between unit-dose pipettes and conventional eye drop bottles. Mean value with 95% confidence interval (n = 41) according to the VAS. VAS, visual analog scale.
FIG. 3.
FIG. 3.
Differences in the results between unit-dose pipettes and conventional eye drop bottles in participants without and with previous experience of eye drop instillation. Mean value with 95% confidence interval (number of participants without previous experience = 30; number of participants with previous experience = 11). VAS, visual analog scale.
FIG. 4.
FIG. 4.
Differences in the results between unit-dose pipettes and conventional eye drop bottles in men and women. Mean value with 95% confidence interval (number of women = 30; number of men = 11). VAS, visual analog scale.
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References

    1. Pisella P.J. Deppasch C. Hamard P., et al. Conjunctival proinflammatory and proapoptotic effects of latanoprost and preserved and unpreserved timolol: an ex vivo and in vitro study. Invest. Ophthalmol. Vis Sci. 2004;45:1360–1368. - PubMed
    1. Baudouin C. Riancho L. Warnet J.M. Brignol F. In vitro studies of antiglaucomatous prostaglandin analogues: travoprost with and without benzalkonium chloride and preserved latanoprost. Invest. Ophthalmol. Vis. Sci. 2007;48:4123–4128. - PubMed
    1. Whitson J.T. Cavanagh H.D. Lakhsman N. Petroll W.M. Assessment of corneal epithelial integrity after acute exposure to ocular hypotensive agents preserved with and without benzalkonium chloride. Adv. Ther. 2006;23:663–671. - PubMed
    1. Noecker R.J. Herrygers L.A. Anwaruddin R. Corneal and conjunctival changes caused by commonly used glaucoma medications. Cornea. 2004;23:490–496. - PubMed
    1. Pisella P.J. Fillacier K. Elena P.P. Debbash C. Baudouin C. Comparison of the effects of preserved and unpreserved formulations of timolol on the ocular surface of albino rabbits. Ophthalmic Res. 2000;32:3–8. - PubMed

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