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Review
. 2010 Jun 17:5:37.
doi: 10.1186/1746-1596-5-37.

Thyroid transcription factor-1 positive primary breast cancer: a case report with review of the literature

Affiliations
Review

Thyroid transcription factor-1 positive primary breast cancer: a case report with review of the literature

Tor A Klingen et al. Diagn Pathol. .

Abstract

This case describes an infiltrating breast tumour with thyroid transcription factor-1 (TTF-1) positive staining and ductal differentiation in a 72-year-old woman. The presence of ductal carcinoma in situ with positive TTF-1 is a strong indication that this is a primary tumour and not a metastasis from lung.On PET scan and CT follow up there were no other tumours found in this patient. We are not aware of any previously reported TTF-1 positive primary breast carcinoma with ductal differentiation.

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Figures

Figure 1
Figure 1
Gross specimen showing well-circumscribed deep seated tumour with yellow necrotic areas.
Figure 2
Figure 2
Tumour with glandular elements, vesicular nuclei and mitoses.
Figure 3
Figure 3
Invasive glandular tumour area is immunoreactive for TTF-1.
Figure 4
Figure 4
CD56 immunoreactivity in a focal invasive tumour area.
Figure 5
Figure 5
CK5/6 immunoreactivity demonstrated in isolated cells within the invasive tumour.
Figure 6
Figure 6
Ductal carcinoma in situ in vicinity of the tumour.
Figure 7
Figure 7
Ductal carcinoma in situ with TTF-1 immunoreactivity.
Figure 8
Figure 8
Ductal carcinoma in situ with CK 5/6 immunoreactivity.

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References

    1. Ordonez NG. Thyroid transcription factor-1 is a marker of lung and thyroid carcinomas. Adv Anat Pathol. 2000;7(2):123–7. doi: 10.1097/00125480-200007020-00007. - DOI - PubMed
    1. Bejarano PA, Baughman RP, Biddinger PW, Miller MA, Fenoglio-Preiser C, al-Kafaji B, Di LR, Whitsett JA. Surfactant proteins and thyroid transcription factor-1 in pulmonary and breast carcinomas. Mod Pathol. 1996;9(4):445–52. - PubMed
    1. Dennis JL, Hvidsten TR, Wit EC, Komorowski J, Bell AK, Downie I, Mooney J, Verbeke C, Bellamy C, Keith WN, Oien KA. Markers of adenocarcinoma characteristic of the site of origin: development of a diagnostic algorithm. Clin Cancer Res. 2005;11(10):3766–72. doi: 10.1158/1078-0432.CCR-04-2236. - DOI - PubMed
    1. Yamamoto J, Ohshima K, Nabeshima K, Ikeda S, Iwasaki H, Kikuchi M. Comparative study of primary mammary small cell carcinoma, carcinoma with endocrine features and invasive ductal carcinoma. Oncol Rep. 2004;11(4):825–31. - PubMed
    1. Ersahin C, Bandyopadhyay S, Bhargava R. Thyroid transcription factor-1 and "basal marker"--expressing small cell carcinoma of the breast. Int J Surg Pathol. 2009;17(5):368–72. doi: 10.1177/1066896909340275. - DOI - PubMed

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