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. 2010 Jun 21:6:4.
doi: 10.1186/1745-9974-6-4.

Objective cough frequency in Idiopathic Pulmonary Fibrosis

Angela L Key #  1   2 , Kimberley Holt #  1   2 , Andrew Hamilton #  3 , Jaclyn A Smith #  3 , John E Earis #  1   2
Affiliations

Objective cough frequency in Idiopathic Pulmonary Fibrosis

Angela L Key et al. Cough. .

Abstract

Background: Cough is a common presenting symptom in patients with Idiopathic Pulmonary Fibrosis (IPF). This study measured cough rates in IPF patients and investigated the association between cough and measures of health related quality of life and subjective cough assessments. In addition, IPF cough rates were related to measures of physiological disease severity and compared to cough rates in health and other respiratory conditions.

Methods: Nineteen IPF patients, mean age 70.8 years +/- 8.6, five female (26.3%) were studied. Subjects performed full pulmonary function testing, 24 hour ambulatory cough recordings, completed a cough related quality of life questionnaire (Leicester Cough Questionnaire) and subjectively scored cough severity with a visual analogue scale. Ambulatory cough recordings were manually counted and reported as number of coughs per hour.

Results: The 24hr cough rates were high (median 9.4, range 1.5-39.4), with day time rates much higher than night time (median 14.6, range 1.9-56.6 compared to 1.9, range 0-19.2, p = 0.003). Strong correlations were found between objective cough frequency and both the VAS (day r = 0.80, p < 0.001, night r = 0.71, p = 0.001) and LCQ (r = -0.80, p < 0.001), but not with measures of pulmonary function. Cough rates in IPF were higher than healthy subjects (p < 0.001) and asthma patients (p < 0.001) but similar to patients with chronic cough (p = 0.33).

Conclusions: This study confirms objectively that cough is a major, very distressing and disabling symptom in IPF patients. The strong correlations between objective cough counts and cough related quality of life measures suggest that in IPF patient's, perception of cough frequency is very accurate.

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Figures

Figure 1
Figure 1
Objective cough frequency (A) and cough VAS scores (B) for day and night in patients with IPF.
Figure 2
Figure 2
Objective cough frequency (24 hour cough rate) and the total score from the LCQ.
Figure 3
Figure 3
Comparison of objective cough frequency in patients with IPF to previously published data in healthy volunteers,[6]asthma[6]and patients presenting with chronic cough.
See this image and copyright information in PMC

References

    1. Coultas DB, Zumwalt RE, Black WC, Sobonya RE. The epidemiology of interstitial lung diseases. Am J Respir Crit Care Med. 1994;150:967–972. - PubMed
    1. Brown KK. Chronic Cough Due to Chronic Interstitial Pulmonary Diseases: ACCP Evidence-Based Clinical Practice Guidelines. Chest. 2006;129:180–185. doi: 10.1378/chest.129.1_suppl.180S. - DOI - PubMed
    1. Swigris JJ, Stewart AL, Gould MK, Wilson SR. Patients' perspectives on how idiopathic pulmonary fibrosis affects the quality of their lives. Health and Quality of Life Outcomes. 2005;3:61. doi: 10.1186/1477-7525-3-61. - DOI - PMC - PubMed
    1. Turner-Warwick M, Burrows B, Johnson A. Cryptogenic fibrosing alveolitis: clinical features and their influence on survival. Thorax. 1980;35:171–180. doi: 10.1136/thx.35.3.171. - DOI - PMC - PubMed
    1. Crystal RG, Fulmer JD, Roberts WC, Moss ML, Line BR, Reynolds HY. Idiopathic pulmonary fibrosis: clinical, histological, radiographic, physiological, scintigraphic, cytological and biochemical aspects. Ann Intern Med. 1976;85:769–788. - PubMed

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