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Comparative Study
. 2010 Jul 19;28(32):5292-300.
doi: 10.1016/j.vaccine.2010.05.048. Epub 2010 Jun 3.

Single versus multi-dose vaccine vials: an economic computational model

Bruce Y Lee  1 , Bryan A Norman, Tina-Marie Assi, Sheng-I Chen, Rachel R Bailey, Jayant Rajgopal, Shawn T Brown, Ann E Wiringa, Donald S Burke
Affiliations
Comparative Study

Single versus multi-dose vaccine vials: an economic computational model

Bruce Y Lee et al. Vaccine. .

Abstract

Single-dose vaccine formats can prevent clinic-level vaccine wastage but may incur higher production, medical waste disposal, and storage costs than multi-dose formats. To help guide vaccine developers, manufacturers, distributors, and purchasers, we developed a computational model to predict the potential economic impact of various single-dose versus multi-dose measles (MEA), hemophilus influenzae type B (Hib), Bacille Calmette-Guérin (BCG), yellow fever (YF), and pentavalent (DTP-HepB-Hib) vaccine formats. Lower patient demand favors fewer dose formats. The mean daily patient arrival thresholds for each vaccine format are as follows: for the MEA vaccine, 2 patients/day (below which the single-dose vial and above which the 10-dose vial are least costly); BCG vaccine, 6 patients/day (below, 10-dose vial; above, 20-dose vial); Hib vaccine, 5 patients/day (below, single-dose vial; above, 10-dose vial); YF vaccine, 33 patients/day (below, 5-dose vials; above 50-dose vial); and DTP-HepB-Hib vaccine, 5 patients/day (below, single-dose vial; above, 10-dose vial).

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Figures

FIGURE 1
FIGURE 1
General Model Structure where: v is the number of doses per vial, n is the total number of patients arriving ÷ v (roundup), and x is the number patients vaccinated. It is assumed that vaccine vials are discarded within 6 hours of reconstitution.
FIGURE 2
FIGURE 2
Vial Utilization Rate by Clinic Demand and Doses per Vial
FIGURE 3(a-c)
FIGURE 3(a-c)
Average Costs per Dose (by Clinic Demand and Doses per Vial) for: (a) Measles Vaccine (b) Vaccine and Disposal, and (c) Vaccine, Disposal and Storage
FIGURE 4(a-c)
FIGURE 4(a-c)
Acceptability Curves for Average Costs per Dose (by Clinic Demand and Doses per Vial) for: (a) Measles Vaccine, (b) Vaccine and Disposal, and (c) Vaccine, Disposal and Storage
See this image and copyright information in PMC

References

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