Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 May 15;6(3):268-81.
doi: 10.7150/ijbs.6.268.

Notch and Wnt signaling, physiological stimuli and postnatal myogenesis

Susan Tsivitse  1
Affiliations
Review

Notch and Wnt signaling, physiological stimuli and postnatal myogenesis

Susan Tsivitse. Int J Biol Sci. .

Abstract

Adult skeletal muscle stem cells, termed satellite cells are imperative to muscle regeneration. Much work has been performed on satellite cell identification and the subsequent activation of the myogenic response but the regulation of satellite cells including its activation is not well elucidated. The purpose of this review article is to synthesize what the literature reveals in regards to the current understanding of satellite cells including their contribution to muscle repair and growth following physiological stimuli. In addition, this review article will describe the recent findings on the roles of the classic developmental signaling pathways, Notch and Wnt, to the myogenic response in various muscle injury models. This purpose of this summary is to bring awareness of the impact that muscle contraction models have on the local and systemic environment of adult muscle stem cells which will be beneficial for comprehending and treatment development for muscle -associated ailments and other organ diseases.

Keywords: Notch and Wnt; muscle repair and growth; physiological stimuli.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: The author has declared that no conflict of interest exists.

Figures

Figure 1
Figure 1
Notch signaling pathway.
Figure 2
Figure 2
Canonical Wnt signaling pathway.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Mauro A. Satellite cell of skeletal muscle fibers. J Biophys Biochem Cytol. 1961;9:493–5. - PMC - PubMed
    1. Conboy I, Rando TA. The regulation of notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis. Developmental Cell. 2002;3:397–409. - PubMed
    1. Conboy I, Conboy MJ, Smythe GM, Rando TA. Notch-mediated restoration of regenerative potential aged muscle. Science. 2003;302:1575–7. - PubMed
    1. Kitzmann M, Bonnieu A, Duret C, Vernus B, Barro M, Laodj-Chevivesse D, Verdi JM, Carnac G. Inhibition of notch signaling induces myotube hypertrophy by recruiting a subpopulation of reserve cells. Journal of Cellular Physiology. 2006;208:538–48. - PubMed
    1. Kuroda K, Tani S, Tamura K, Minoguchi S, Kurooka H, Honjo T. Delta-induced notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis. The Journal of Biological Chemistry. 1999;274(11):7238–44. - PubMed

MeSH terms