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. 2010 Nov;28(9):958-62.
doi: 10.3109/07357907.2010.483510.

Cleft lip and palate in family members of cancer survivors

E Taioli  1 , C Ragin, L Robertson, F Linkov, N E Thurman, A R Vieira
Affiliations

Cleft lip and palate in family members of cancer survivors

E Taioli et al. Cancer Invest. 2010 Nov.

Abstract

The presence of cleft lip with or without cleft palate (CL/P) in family members of cancer patients was investigated. An epidemiological questionnaire including family history of cancer and congenital oral cleft malformations was administered to 168 cancer survivors and a population-based sample of 170 healthy subjects. In the control group, 1.2% reported a family member with CL/P; among cancer survivors the figure was 4.2% (odds ratio: 3.7; 95% confidence interval: 0.75–17.8; p = .07). Among cancer survivors with a family member with CL/P, there was an apparent excess of testicular cancer and melanoma in comparison with the cancer survivors with no family history of CL/P. These preliminary results suggest a common etiologic background for cancer and CL/P.

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Conflict of interest statement

DECLARATION OF INTEREST

The authors report no conflicts of interest.

Figures

Figure 1
Figure 1
Schematic graphs utilized for the questionnaire to identify family members with CL/P.
See this image and copyright information in PMC

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