Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Nov;28(9):958-62.
doi: 10.3109/07357907.2010.483510.

Cleft lip and palate in family members of cancer survivors

E Taioli  1 , C Ragin, L Robertson, F Linkov, N E Thurman, A R Vieira
Affiliations

Cleft lip and palate in family members of cancer survivors

E Taioli et al. Cancer Invest. 2010 Nov.

Abstract

The presence of cleft lip with or without cleft palate (CL/P) in family members of cancer patients was investigated. An epidemiological questionnaire including family history of cancer and congenital oral cleft malformations was administered to 168 cancer survivors and a population-based sample of 170 healthy subjects. In the control group, 1.2% reported a family member with CL/P; among cancer survivors the figure was 4.2% (odds ratio: 3.7; 95% confidence interval: 0.75–17.8; p = .07). Among cancer survivors with a family member with CL/P, there was an apparent excess of testicular cancer and melanoma in comparison with the cancer survivors with no family history of CL/P. These preliminary results suggest a common etiologic background for cancer and CL/P.

PubMed Disclaimer

Conflict of interest statement

DECLARATION OF INTEREST

The authors report no conflicts of interest.

Figures

Figure 1
Figure 1
Schematic graphs utilized for the questionnaire to identify family members with CL/P.
See this image and copyright information in PMC

References

    1. Windham GC, Bjerkedal T, Langmark F. A population-based study of cancer incidence in twins and in children with congenital malformations or low birth weight, Norway, 1967–1980. J. Am Epidemiol. 1985;121:49–56. - PubMed
    1. Mili F, Khoury MJ, Flanders WD, Greenberg RS. Risk of childhood cancer for infants with birth defects. I. A record-linkage study, Atlanta, Georgia, 1968–1988. J. Am Epidemiol. 1993;137:629–638. - PubMed
    1. Mili F, Lynch CF, Khoury MJ, Flanders WD, Edmonds LD. Risk of childhood cancer for infants with birth defects. II. A record-linkage study, Iowa, 1983–1989. J. Am Epidemiol. 1993;137:639–644. - PubMed
    1. Narod SA, Hawkins MM, Robertson CM, Stiller CA. Congenital anomalies and childhood cancer in B. Greatritain. J. Am G. Humenet. 1997;60:474–485. - PMC - PubMed
    1. Mossey PA, Little J. Epidemiology of oral clefts: an international perspective. C. In: Wyszynski DF, editor. Inleft Lip and Palate: O. Fromrigin to Treatment. New York, NY: Oxford University Press; 2002. pp. 127–158.

Publication types