Orbitofrontal volume reductions during emotion recognition in patients with major depression

Abstract

Background: Major depressive disorder is associated with both structural and functional alterations in the emotion regulation network of the central nervous system. The relation between structural and functional changes is largely unknown. Therefore, we sought to determine the relation between structural differences and functional alterations during the recognition of emotional facial expressions.

Methods: We examined 13 medication-free patients with major depression and 15 healthy controls by use of structural T1-weighted high-resolution magnetic resonance imaging (MRI) and functional MRI during 1 session. We set the statistical threshold for the analysis of imaging data to p < 0.001 (uncorrected).

Results: As shown by voxel-based morphometry, depressed patients had reductions in orbitofrontal cortex volume and increases in cerebellar volume. Additionally, depressed patients showed increased activity during emotion recognition in the middle frontal cortex, caudate nucleus, precuneus and lingual gyrus. Within this cerebral network, the orbitofrontal volumes were negatively correlated in depressed patients but not in healthy controls with changes in blood oxygen level-dependent signal in the middle frontal gyrus, caudate nucleus, precuneus and supplementary motor area.

Limitations: Our results are limited by the relatively small sample size.

Conclusions: This combined functional and structural MRI study provides evidence that the orbitofrontal cortex is a key area in major depression and that structural changes result in functional alterations within the emotional circuit. Whether these alterations in the orbitofrontal cortex are also related to persistent emotional dysfunction in remitted mental states and, therefore, are related to the risk of depression needs further exploration.

Fig. 1

Examples of the explicit and implicit triplets and the control stimuli used in this emotional paradigm.

Fig. 2

Negative correlation of the orbitofrontal cortex volume reduction (blue) and cerebral activity of dorsolateral prefrontal cortex, caudatus, precuneus and supplementary motor area during emotion recognition (orange) in patients with major depression (p < 0.001, uncorrected).

Fig. 3

Scatterplots and correlation coefficients (r) for the association between orbitofrontal cortex volume and cerebral activity of the dorsolateral prefrontal cortex, caudatus, precuneus and supplementary motor area for patients with major depression and healthy controls. Note that the regression slopes were significantly different between patients with major depression and healthy controls in the statistical parametric mapping analysis. The regression slope is shown only for the patients with major depression, because the slope was not significant for the controls.