Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Jun;37(2):339-54.
doi: 10.1016/j.clp.2010.02.003.

Diagnosis and management of clinical chorioamnionitis

Alan T N Tita  1 , William W Andrews
Affiliations
Review

Diagnosis and management of clinical chorioamnionitis

Alan T N Tita et al. Clin Perinatol. 2010 Jun.

Abstract

Chorioamnionitis is a common complication of pregnancy associated with significant maternal, perinatal, and long-term adverse outcomes. Adverse maternal outcomes include postpartum infections and sepsis whereas adverse infant outcomes include stillbirth, premature birth, neonatal sepsis, chronic lung disease, and brain injury leading to cerebral palsy and other neurodevelopmental disabilities. Research in the past 2 decades has expanded understanding of the mechanistic links between intra-amniotic infection and preterm delivery as well as morbidities of preterm and term infants. Recent and ongoing clinical research into better methods for diagnosing, treating, and preventing chorioamnionitis is likely to have a substantial impact on short and long-term outcomes in the neonate.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Routes of chorioamnionitis/funisitis
Figure 2
Figure 2
Pathogenesis of Chorioamnionitis: Maternal and Fetal Response and Complications IL=Interleukin, TNF=Tumor Necrosis Factor, MMP=Matrix metalloproteinase, FIRS=Fetal Inflammatory Response Syndrome, PTB Preterm birth
See this image and copyright information in PMC

References

    1. Eschenbach DA. Ureaplasma urealyticum and premature birth. Clin Infect Dis. 1993;17 (Suppl 1):S100–6. - PubMed
    1. Gibbs RS, Duff P. Progress in pathogenesis and management of clinical intraamniotic infection. Am J Obstet Gynecol. 1991;164:1317. - PubMed
    1. Soper DE, Mayhall CG, Dalton HP. Risk factors for intraamniotic infection: a prospective epidemiologic study. Am J Obstet Gynecol. 1989;161:562. - PubMed
    1. Newton ER. Chorioamnionitis and intraamniotic infection. Clin Obstet Gynecol. 1993;36:795. - PubMed
    1. Newton ER, Prihoda TJ, Gibbs RS. Logistic regression analysis of risk factors for intra-amniotic infection. Obstet Gynecol. 1989;73:571. - PubMed

Publication types

MeSH terms