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. 2010 Jul 1;20(13):3941-5.
doi: 10.1016/j.bmcl.2010.05.008. Epub 2010 May 10.

2-Substituted N-aryl piperazines as novel triple reuptake inhibitors for the treatment of depression

David S Carter  1 , Hai-Ying Cai, Eun Kyung Lee, Pravin S Iyer, Matthew C Lucas, Ralf Roetz, Ryan C Schoenfeld, Robert J Weikert
Affiliations

2-Substituted N-aryl piperazines as novel triple reuptake inhibitors for the treatment of depression

David S Carter et al. Bioorg Med Chem Lett. .

Abstract

Recently a class of compounds known as triple reuptake inhibitors has emerged as a new strategy for the treatment of depression. These compounds work by simultaneously inhibiting the synaptic reuptake of serotonin, norepinephrine and dopamine. In this Letter we describe the optimization of a novel series of 2-substituted N-aryl piperazine based triple reuptake inhibitors.

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