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. 2011 May;53(5):343-8.
doi: 10.1007/s00234-010-0726-1. Epub 2010 Jun 23.

Long-term MRA follow-up after coiling of intracranial aneurysms: impact on mood and anxiety

Sandra P Ferns  1 , Pythia T Nieuwkerk, Willem Jan J van Rooij, Gabriël J E Rinkel, Charles B L M Majoie
Affiliations

Long-term MRA follow-up after coiling of intracranial aneurysms: impact on mood and anxiety

Sandra P Ferns et al. Neuroradiology. 2011 May.

Abstract

Introduction: Magnetic resonance angiography (MRA) screening for recurrence of a coiled intracranial aneurysm and formation of new aneurysms long-term after coiling may induce anxiety and depression. In coiled patients, we evaluated effects on mood and level of anxiety from long-term follow-up MRA in comparison to general population norms.

Methods: Of 162 patients participating in a long-term (>4.5 years) MRA follow-up after coiling, 120 completed the EQ-5D questionnaire, a visual analog health scale and a self-developed screening related questionnaire at the time of MRA. Three months later, the same questionnaires were completed by 100 of these 120 patients. Results were compared to general population norms adjusted for gender and age.

Results: Any problem with anxiety or depression was reported in 56 of 120 patients (47%; 95%CI38↔56%) at baseline and 42 of 100 patients (42%; 95%CI32↔52%) at 3 months, equally for screen-positives and -negatives. Compared to the reference population, participants scored 38% (95%CI9↔67%) and 27% (95%CI4↔50%) more often any problem with anxiety or depression. Three months after screening, 21% (20 of 92) of screen-negatives and 13% (one of eight) of screen-positives reported to be less afraid of subarachnoid hemorrhage (SAH) compared to before screening. One of eight screen-positives reported increased fear of SAH.

Conclusions: Patients with coiled intracranial aneurysms participating in long-term MRA screening reported significantly more often to be anxious or depressed than a reference group. Screening did not significantly increase anxiety or depression temporarily. However, subjectively, patients did report an increase in anxiety caused by screening, which decreased after 3 months.

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Figures

Fig. 1
Fig. 1
Patients’ response to the screening related questions at MRI screening and after 3 months
Fig. 2
Fig. 2
Flowchart showing patient selection for the LOTUS study and the present sub-study
Fig. 3
Fig. 3
Patients’ response to “Are you anxious or depressed?” question at MRI screening and after 3 months
Fig. 4
Fig. 4
Patients reporting to have ‘any problem’ with anxiety or depression in the EQ-5D questionnaire at MRI screening and after 3 months compared to Dutch general population norms
See this image and copyright information in PMC

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