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Comparative Study
. 2010 Oct;64(4):496-9.
doi: 10.1007/s11418-010-0435-4. Epub 2010 Jun 23.

Juglanone, a novel α-tetralonyl derivative with potent antioxidant activity from Juglans mandshurica

Lijuan Liu  1 , Wei Li, Tatsunori Sasaki, Yoshihisa Asada, Kazuo Koike
Affiliations
Comparative Study

Juglanone, a novel α-tetralonyl derivative with potent antioxidant activity from Juglans mandshurica

Lijuan Liu et al. J Nat Med. 2010 Oct.

Abstract

A novel alpha-tetralonyl derivative, juglanone, was isolated from the fresh unripe fruits of Juglans mandshurica. Its structure was determined by spectroscopic analyses and from chemical evidence. Juglanone exhibited significant antioxidant activity in assays for 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity and superoxide dismutase-like activity with IC(50) values of 10.1 and 9.0 microM, respectively. It also showed moderate cytotoxic activity against HL-60 human myeloid leukemia with an IC(50) value of 19.7 microM.

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