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. 2010 Sep;45(9):3993-7.
doi: 10.1016/j.ejmech.2010.05.055. Epub 2010 Jun 2.

Synthesis and preliminary bioactivity assays of 3,4-dichloro-5-(omega-hydroxyalkylamino)-2(5H)-furanones

Edyta Gondela  1 , Krzysztof Z Walczak
Affiliations

Synthesis and preliminary bioactivity assays of 3,4-dichloro-5-(omega-hydroxyalkylamino)-2(5H)-furanones

Edyta Gondela et al. Eur J Med Chem. 2010 Sep.

Abstract

5-(Omega-hydroxyalkylamino) derivatives of mucochloric acids were synthesized through a facile substitution reaction of 3,4-dichloro-5-hydroxy-2(5H)-furanone (mucochloric acid) acetate or 5-methylcarbonate with an appropriate amino alcohol or aminodiol. The obtained products were characterized and screened for their antibacterial and antiprotozoal activities.

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