Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Jul;10(7):505-14.
doi: 10.1038/nrc2868.

Targeting the tumour vasculature: insights from physiological angiogenesis

Alicia S Chung  1 , John Lee, Napoleone Ferrara
Affiliations
Review

Targeting the tumour vasculature: insights from physiological angiogenesis

Alicia S Chung et al. Nat Rev Cancer. 2010 Jul.

Abstract

The cardiovascular system ensures the delivery of nutrients, oxygen, and blood and immune cells to all organs and tissues: it is also responsible for the removal of waste metabolites. The vascular system develops and matures through two tightly regulated processes: vasculogenesis and angiogenesis. Angiogenesis is active only under specific physiological conditions in healthy adults but the vasculature can be aberrantly activated to generate new blood vessels during pathological conditions such as cancer and chronic inflammation. In this Opinion article we discuss the parallels and differences in the angiogenic process under either a physiological or a pathological state, especially tumorigenesis.

PubMed Disclaimer

References

    1. Cancer Cell. 2008 Oct 7;14(4):299-311 - PubMed
    1. Toxicol Pathol. 1999 Jan-Feb;27(1):78-86 - PubMed
    1. Wiley Interdiscip Rev Syst Biol Med. 2010 May-Jun;2(3):336-361 - PubMed
    1. Leuk Res. 2007 Apr;31(4):439-44 - PubMed
    1. Proc Natl Acad Sci U S A. 2008 May 6;105(18):6620-5 - PubMed

LinkOut - more resources