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Case Reports
. 2009 Jun;5(6):418-24.

Collagenous sprue: a case report and literature review

Zuoliang Xiao, Vijaya M Dasari, Donald F Kirby, Mary Bronner, Thomas P Plesec, Bret A Lashner
Case Reports

Collagenous sprue: a case report and literature review

Zuoliang Xiao et al. Gastroenterol Hepatol (N Y). 2009 Jun.
No abstract available

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Figures

Figure 1
Figure 1
Jejunal biopsy demonstrating near-total villous atrophy with prominent subepithelial collagen table that is irregular and incorporates capillaries and cell nuclei. The surface epithelium shows mucin loss and is sloughed (hematoxylin and eosin stain, 200×).
Figure 2
Figure 2
Subsequent jejunal biopsy reveals similar findings as found in the initial jejunal biopsy (Figure 1). At this higher power magnification, the subepithelial collagen table is remarkably thickened and has an irregular interface with the lamina propria (hematoxylin and eosin stain, 400×).
Figure 3
Figure 3
Multiple colon biopsies reveal collagenous colitis characterized by essentially intact crypt architecture with top-heavy lymphoplasmacytic lamina propria infiltrate and an irregular and thickened subepithelial collagen table (hematoxylin and eosin stain, 200×).
Figure 4
Figure 4
Most recent colon biopsies of the patient reveal normal crypt architecture, no enterocyte injury, and unremarkable subepithelial collagen table (hematoxylin and eosin stain, 200×).
See this image and copyright information in PMC

References

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    1. Weinstein WM, Saunders DR, Tytgat GN, Rubin CE. Collagenous sprue--an unrecognized type of malabsorption. N Engl J Med. 1970;283:1297–1301. - PubMed
    1. Robert ME, Ament ME, Weinstein WM. The histologic spectrum and clinical outcome of refractory and unclassified sprue. Am J Surg Pathol. 2000;24:676–687. - PubMed
    1. Hafkemeyer P, Herbst E, Köhler G, Fuhrmann K, Kreisel W. Collagenous sprue. Dtsch Med Wochenschr. 1995;120:1430–1434. - PubMed
    1. Holdstock DJ, Oleesky S. Successful treatment of collagenous sprue with combination of prednisolone and gluten free diet. Postgrad Med J. 1973;49:664–667. - PMC - PubMed

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