Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Jun 24:5:58.
doi: 10.1186/1748-717X-5-58.

Helical tomotherapy for single and multiple liver tumours

Tsair-Fwu Lee  1 , Pei-Ju Chao, Fu-Min Fang, Te-Jen Su, Stephen W Leung, Hsuan-Chih Hsu
Affiliations

Helical tomotherapy for single and multiple liver tumours

Tsair-Fwu Lee et al. Radiat Oncol. .

Abstract

Purpose: Dosimetric evaluations of single and multiple liver tumours performed using intensity-modulated helical tomotherapy (HT) were quantitatively investigated. Step-and-shoot intensity-modulated radiotherapy (SaS-IMRT) was used as a benchmark.

Methods: Sixteen patients separated into two groups with primary hepatocellular carcinomas or metastatic liver tumours previously treated using SaS-IMRT were examined and re-planned by HT. The dosimetric indices used included the conformity index (CI) and homogeneity index (HI) for the planned target volume (PTV), max/mean dose, quality index (QI), normal tissue complication probability (NTCP), V(30 Gy), and V(50%) for the specified organs at risk (OARs). The monitor units per fraction (MU/fr) and delivery time were also analysed.

Results: For the single tumour group, both planning systems satisfied the required PTV prescription, but no statistical significance was shown by the indexes checking. A shorter delivery time and lower MU/fr value were achieved by the SaS-IMRT. For the group of multiple tumours, the average improvement in CI and HI was 14% and 4% for HT versus SaS-IMRT, respectively. Lower V(50%), V(30 Gy) and QI values were found, indicating a significant dosimetric gain in HT. The NTCP value of the normal liver was 20.27 +/- 13.29% for SaS-IMRT and 2.38 +/- 2.25% for HT, indicating fewer tissue complications following HT. The latter also required a shorter delivery time.

Conclusions: Our study suggests dosimetric benefits of HT over SaS-IMRT plans in the case of multiple liver tumours, especially with regards sparing of OARs. No significant dosimetric difference was revealed in the case of single liver tumour, but SaS-IMRT showed better efficiency in terms of MU/fr and delivery time.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The comparison of isodose distributions of planned target volume (PTV) and organs at risk (OARs) in an axial plane for one patient in group 1 using the helical tomotherapy (HT) planning system versus step-and-shoot intensity-modulated radiotherapy (SaS-IMRT). DVH: Dose volume histograms; PTV = Planning target volume; OAR = Organ at risk
Figure 2
Figure 2
The comparison of isodose distributions of planned target volume (PTV) and organs at risk (OARs) in an axial plane for one patient in group 2 using the helical tomotherapy (HT) planning system versus step-and-shoot intensity-modulated radiotherapy (SaS-IMRT). DVH: Dose volume histograms; PTV = Planning target volume; OAR = Organ at risk
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Kiyosawa K, Umemura T, Ichijo T, Matsumoto A, Yoshizawa K, Gad A, Tanaka E. Hepatocellular carcinoma: Recent trends in Japan. Gastroenterology. 2004;127:S17–S26. doi: 10.1053/j.gastro.2004.09.012. - DOI - PubMed
    1. Thomas MB, Abbruzzese JL. Opportunities for targeted therapies in hepatocellular carcinoma. Journal of Clinical Oncology. 2005;23:8093. doi: 10.1200/JCO.2004.00.1537. - DOI - PubMed
    1. Kao Y-H, Chen C-N, Chiang J-K, Chen S-S, Huang W-W. Predicting Factors in the Last Week of Survival in Elderly Patients with Terminal Cancer: A Prospective Study in Southern Taiwan. Journal of the Formosan Medical Association. 2009;108:231–239. doi: 10.1016/S0929-6646(09)60057-7. - DOI - PubMed
    1. Cha CH, Ruo L, Fong Y, Jarnagin WR, Shia J, Blumgart LH, DeMatteo RP. Resection of hepatocellular carcinoma in patients otherwise eligible for transplantation. Ann Surg. 2003;238:315. - PMC - PubMed
    1. Dae Yong K, Won P, Do Hoon L, Joon Hyoek L, Byung Chul Y, Seung Woon P, Kwang Cheol K, Tae Hyun K, Yong Chan A, Seung Jae H. Three-dimensional conformal radiotherapy for portal vein thrombosis of hepatocellular carcinoma. Cancer. 2005;103:2419–2426. doi: 10.1002/cncr.21043. - DOI - PubMed

Publication types