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. 2010 Sep;45(9):4058-64.
doi: 10.1016/j.ejmech.2010.05.065. Epub 2010 Jun 8.

3-Formylchromones: potential antiinflammatory agents

Khalid M Khan  1 , Nida Ambreen, Uzma Rasool Mughal, Saima Jalil, Shahnaz Perveen, M Iqbal Choudhary
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3-Formylchromones: potential antiinflammatory agents

Khalid M Khan et al. Eur J Med Chem. 2010 Sep.

Abstract

The synthesis and characterization of 3-formylchromone (1) and its derivatives 2-24 and evaluation of their potential antiinflammatory activities is reported here. These compounds were characterized by (1)H NMR, EI MS, IR, and UV spectroscopic techniques and elemental analysis. The synthesized compounds were evaluated by using various in vitro and in vivo assay models for antiinflammatory activity and their effects were compared with known standard drug such as aspirin and indomethacin. Among all tested compounds, 1, 2, 5, 6, 9, 14, 16-19, 21-23, showed promising antiinflammatory activities. The results and SAR has been discussed in this report.

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