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Comment
. 2010 Jun 25;328(5986):1646-7.
doi: 10.1126/science.1192488.

Immunology. IgA changes the rules of memory

Andrea Cerutti  1
Affiliations
Comment

Immunology. IgA changes the rules of memory

Andrea Cerutti. Science. .
No abstract available

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Figures

None
Intestinal IgA dynamics
Dendritic cells sample commensal bacteria from the intestinal lumen and migrate to follicles, where they present antigen to T cells. T cells and dendritic cells in the follicles stimulate B cells to mature and produce IgA. B cells then enter lymphatic and blood vessels. After about 14 days, they enter the lamina propria and differentiate into long-lived (more than 16 weeks) plasma cells that release IgA dimers. Dimers enter the intestinal lumen and function as secretory IgA. Exposure to a different commensal rapidly attenuates an ongoing response (attrition).
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References

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