Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2010 Jun 24;465(7301):E1; discussion E3.
doi: 10.1038/nature09089.

Human adult germline stem cells in question

Kinarm Ko  1 , Marcos J Araúzo-Bravo, Natalia Tapia, Julee Kim, Qiong Lin, Christof Bernemann, Dong Wook Han, Luca Gentile, Peter Reinhardt, Boris Greber, Rebekka K Schneider, Sabine Kliesch, Martin Zenke, Hans R Schöler
Affiliations
Comparative Study

Human adult germline stem cells in question

Kinarm Ko et al. Nature. .

Abstract

Conrad et al. have generated human adult germline stem cells (haGSCs) from human testicular tissue, which they claim have similar pluripotent properties to human embryonic stem cells (hESCs). Here we investigate the pluripotency of haGSCs by using global gene-expression analysis based on their gene array data and comparing the expression of pluripotency marker genes in haGSCs and hESCs, and in haGSCs and human fibroblast samples derived from different laboratories, including our own. We find that haGSCs and fibroblasts have a similar gene-expression profile, but that haGSCs and hESCs do not. The pluripotency of Conrad and colleagues' haGSCs is therefore called into question.

PubMed Disclaimer

Comment on

References

    1. Science. 2009 May 8;324(5928):797-801 - PubMed
    1. Nucleic Acids Res. 2003 Feb 15;31(4):e15 - PubMed
    1. In Vitro. 1975 Sep-Oct;11(5):313-21 - PubMed
    1. Nat Biotechnol. 2008 Nov;26(11):1276-84 - PubMed
    1. Cell Stem Cell. 2009 Jul 2;5(1):87-96 - PubMed

MeSH terms

Associated data