A GENERAL ASYMPTOTIC THEORY FOR MAXIMUM LIKELIHOOD ESTIMATION IN SEMIPARAMETRIC REGRESSION MODELS WITH CENSORED DATA
- PMID: 20577580
- PMCID: PMC2888521
A GENERAL ASYMPTOTIC THEORY FOR MAXIMUM LIKELIHOOD ESTIMATION IN SEMIPARAMETRIC REGRESSION MODELS WITH CENSORED DATA
Abstract
We establish a general asymptotic theory for nonparametric maximum likelihood estimation in semiparametric regression models with right censored data. We identify a set of regularity conditions under which the nonparametric maximum likelihood estimators are consistent, asymptotically normal, and asymptotically efficient with a covariance matrix that can be consistently estimated by the inverse information matrix or the profile likelihood method. The general theory allows one to obtain the desired asymptotic properties of the nonparametric maximum likelihood estimators for any specific problem by verifying a set of conditions rather than by proving technical results from first principles. We demonstrate the usefulness of this powerful theory through a variety of examples.
Similar articles
-
Maximum likelihood estimation for semiparametric regression models with multivariate interval-censored data.Biometrika. 2017 Sep;104(3):505-525. doi: 10.1093/biomet/asx029. Epub 2017 Jul 12. Biometrika. 2017. PMID: 29391606 Free PMC article.
-
Semiparametric Maximum Likelihood Estimation in Normal Transformation Models for Bivariate Survival Data.Biometrika. 2008 Dec;95(4):947-960. doi: 10.1093/biomet/asn049. Biometrika. 2008. PMID: 19079778 Free PMC article.
-
Collaborative double robust targeted maximum likelihood estimation.Int J Biostat. 2010 May 17;6(1):Article 17. doi: 10.2202/1557-4679.1181. Int J Biostat. 2010. PMID: 20628637 Free PMC article.
-
Semiparametric Regression Analysis of Multiple Right- and Interval-Censored Events.J Am Stat Assoc. 2019;114(527):1232-1240. doi: 10.1080/01621459.2018.1482756. Epub 2018 Aug 17. J Am Stat Assoc. 2019. PMID: 31588157 Free PMC article.
-
Additive hazards model with auxiliary subgroup survival information.Lifetime Data Anal. 2019 Jan;25(1):128-149. doi: 10.1007/s10985-018-9426-7. Epub 2018 Feb 22. Lifetime Data Anal. 2019. PMID: 29470696 Review.
Cited by
-
Estimating treatment effects with treatment switching via semicompeting risks models: an application to a colorectal cancer study.Biometrika. 2012 Mar;99(1):167-184. doi: 10.1093/biomet/asr062. Epub 2011 Dec 29. Biometrika. 2012. PMID: 23049136 Free PMC article.
-
SEMIPARAMETRIC LATENT-CLASS MODELS FOR MULTIVARIATE LONGITUDINAL AND SURVIVAL DATA.Ann Stat. 2022 Feb;50(1):487-510. doi: 10.1214/21-aos2117. Epub 2022 Feb 16. Ann Stat. 2022. PMID: 35813218 Free PMC article.
-
SEMIPARAMETRIC TRANSFORMATION MODELS WITH MULTILEVEL RANDOM EFFECTS FOR CORRELATED DISEASE ONSET IN FAMILIES.Stat Sin. 2019;29(4):1851-1871. doi: 10.5705/ss.202017.0326. Stat Sin. 2019. PMID: 31579362 Free PMC article.
-
Estimation of treatment effects and model diagnostics with two-way time-varying treatment switching: an application to a head and neck study.Lifetime Data Anal. 2020 Oct;26(4):685-707. doi: 10.1007/s10985-020-09495-0. Epub 2020 Mar 3. Lifetime Data Anal. 2020. PMID: 32125594 Free PMC article.
-
Analysis of multiple diverse phenotypes via semiparametric canonical correlation analysis.Biometrics. 2017 Dec;73(4):1254-1265. doi: 10.1111/biom.12690. Epub 2017 Apr 13. Biometrics. 2017. PMID: 28407213 Free PMC article.
References
-
- Heitjan DF, Rubin DB. Ignorability and coarse data. Ann Statist. 1991;19:2244–2253.
-
- Murphy SA. Consistency in a proportional hazards model incorporating a random effect. Ann Statist. 1994;22:712–731.
-
- Murphy SA. Asymptotic theory for the frailty model. Ann Statist. 1995;23:182–198.
-
- Murphy SA, van der Vaart AW. On profile likelihood. J Am Statist Assoc. 2000;95:449–485.
-
- Murphy SA, van der Vaart AW. Semiparametric mixtures in case-control studies. J Multi Analy. 2001;79:1–32.
Grants and funding
LinkOut - more resources
Full Text Sources