Prostate cancer metastasis to the stomach

Abstract

Prostate cancer commonly manifests with bony metastases. Visceral metastasis can also occur in the lungs and liver. However, stomach metastasis related to prostate cancer is rare. Here, we report a case of prostate cancer metastatic to the stomach. A 66-year-old male was diagnosed with prostate adenocarcinoma. He was noted as having abdominal discomfort, nausea, and vomiting 18 months after the diagnosis. A histopathologic examination and an esophagogastroduodenoscopic gastric biopsy revealed stomach-metastatic adenocarcinoma. He was also noted as having cerebellar metastatic lesions, which were identified by using a brain magnetic resonance imaging (MRI) scan. The patient died of cardiovascular complications 5 months after the diagnosis of stomach metastasis.

Keywords: Neoplasm metastasis; Prostatic neoplasms.

FIG. 1

Esophagogastroduodenoscopy: Multiple small elevated mucosal ulcerations on the anterior wall of the gastric antrum are shown (black arrow).

FIG. 2

Histopathology of the gastric biopsy. (A) Infiltration of neoplastic cells with marked atypical nucleoli and abundant eosinophilic cytoplasm (H&E, ×100). (B) Positive response of prostate-specific antigen (PSA) stain: the color of the cytoplasm in neoplastic cells changed to brown (PSA stain, ×200).

FIG. 3

Brain magnetic resonance imaging (MRI) scan showing a 2×1.6 cm mass with an irregular margin and a high signal intensity in the base of the right cerebellum (black arrow).