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Comparative Study
. 2010 Aug 1;51(3):e24-7.
doi: 10.1086/654801.

Serologic assays specific to immunoglobulin M antibodies against hepatitis E virus: pangenotypic evaluation of performances

Jan Drobeniuc  1 , Jihong Meng, Gábor Reuter, Tracy Greene-Montfort, Natasha Khudyakova, Zoya Dimitrova, Saleem Kamili, Chong-Gee Teo
Affiliations
Comparative Study

Serologic assays specific to immunoglobulin M antibodies against hepatitis E virus: pangenotypic evaluation of performances

Jan Drobeniuc et al. Clin Infect Dis. .

Abstract

Six immunoassays for detecting immunoglobulin M antibodies to hepatitis E virus were evaluated. Serum samples representing acute infection by each of the 4 viral genotypes as well as nonacute hepatitis E virus infection constituted the test panels. Diagnostic sensitivities and specificities as well as interassay agreement varied widely. Analytical sensitivity limits also were determined and were found to be particularly disparate.

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