HLA-A, -B, -DR, -DQ antigens in black North Americans

Abstract

HLA antigens of black North Americans are not as well-characterized as those of other ethnic groups. We present results from HLA typing of black Americans using the 10th International Histocompatibility Workshop (IHW) sera. 1502 black Americans are typed for HLA-A, -B antigens. 128 black Americans are typed for HLA-DR, -DQ antigens. New specificities and splits established by the 10th IHW are identified in our data. Antigen frequency, gene frequency and haplotype frequency are computed for each phenotype observed. Haplotype A30--Bw42--DRw18--DQw4 and haplotype Aw36--Bw53 in strong linkage disequilibrium is characteristic of this black population. DR and DQ association patterns are similar to those of white North Americans. A major difference is the association of DRw8 with DQw7 in blacks versus an association of DRw8 with DQw4 in whites.