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Randomized Controlled Trial
. 2010 Aug;203(2):105.e1-13.
doi: 10.1016/j.ajog.2010.01.049. Epub 2010 Jul 1.

Uterine artery embolization vs hysterectomy in the treatment of symptomatic uterine fibroids: 5-year outcome from the randomized EMMY trial

Sanne M van der Kooij  1 , Wouter J K Hehenkamp, Nicole A Volkers, Erwin Birnie, Willem M Ankum, Jim A Reekers
Affiliations
Randomized Controlled Trial

Uterine artery embolization vs hysterectomy in the treatment of symptomatic uterine fibroids: 5-year outcome from the randomized EMMY trial

Sanne M van der Kooij et al. Am J Obstet Gynecol. 2010 Aug.

Abstract

Objective: The purpose of this study was to compare clinical outcome and health related quality of life (HRQOL) 5 years after uterine artery embolization (UAE) or hysterectomy in the treatment of menorrhagia caused by uterine fibroids.

Study design: Patients with symptomatic uterine fibroids who were eligible for hysterectomy were assigned randomly 1:1 to hysterectomy or UAE. Endpoints after 5 years were reintervention rates, menorrhagia, and HRQOL measures that were assessed by validated questionnaires.

Results: Patients were assigned randomly to UAE (n = 88) or hysterectomy (n = 89). Five years after treatment 23 of 81 UAE patients (28.4%) had undergone a hysterectomy because of insufficient improvement of complaints (24.7% after successful UAE). HRQOL measures improved significantly and remained stable until the 5-year follow-up evaluation, with no differences between the groups. UAE had a positive effect both on urinary and defecation function.

Conclusion: UAE is a well-established alternative to hysterectomy about which patients should be counseled.

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