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. 2010 Sep 1;68(5):491-3.
doi: 10.1016/j.biopsych.2010.05.010. Epub 2010 Jun 26.

Decreased prefrontal cortical volume associated with increased bedtime cortisol in traumatized youth

Victor G Carrion  1 , Carl F Weems, Kit Richert, Bryce C Hoffman, Allan L Reiss
Affiliations

Decreased prefrontal cortical volume associated with increased bedtime cortisol in traumatized youth

Victor G Carrion et al. Biol Psychiatry. .

Abstract

Background: The purpose of this study was to investigate prefrontal cortex (PFC) volumes in youth with posttraumatic stress symptoms (PTSS) and explore the relationship between cortisol secretion and PFC volumes.

Methods: Total brain tissue volumes, segmented areas of the PFC, and diurnal cortisol secretion were examined in a sample of 33 youth aged 10 to 16 years. Cerebral volumes were available for 45 subjects (30 PTSS and 15 control subjects).

Results: Youth with PTSS had significantly decreased total brain tissue and total cerebral gray volumes in comparison with healthy control subjects. While controlling for total cerebral gray volume, the PTSS group demonstrated decreased left ventral and left inferior prefrontal gray volumes. A significant negative association was found between prebedtime cortisol levels and left ventral PFC gray volumes for the full sample.

Conclusions: Findings suggest associations between posttraumatic stress and PFC neurodevelopment. Findings also suggest a link between PFC development and cortisol secretion.

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Figures

Figure 1
Figure 1. Division of the PFC into dorsal, superior, inferior, and ventral regions
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Comment in

  • Cortisol and brain: beyond the hippocampus.
    Kremen WS, Panizzon MS, Lyons MJ, Franz CE. Kremen WS, et al. Biol Psychiatry. 2011 Feb 15;69(4):e9; author reply e11. doi: 10.1016/j.biopsych.2010.08.035. Epub 2010 Nov 20. Biol Psychiatry. 2011. PMID: 21093849 No abstract available.

References

    1. Shimamura AP. The role of the prefrontal cortex in dynamic filtering. Psychobiology. 2000;28:207–218.
    1. Carrion VG, Weems CF, Eliez S, Patwardhan A, Brown W, Ray R, Reiss AL. Attenuation of frontal lobe asymmetry in pediatric PTSD. Biological Psychiatry. 2001;50:943–951. - PubMed
    1. De Bellis MD, Keshavan MS, Shifflett H, Iyengar S, Beers SR, Hall J, Moritz G. Brain structures in pediatric maltreatment-related posttraumatic stress disorder; a sociodemographically matched study. Biological Psychiatry. 2002;52:1066–1078. - PubMed
    1. Perry BD. Childhood experience and the expression of genetic potential: What childhood neglect tells us about nature and nurture. Brain and Mind. 2002;3:79–100.
    1. Bremner JD, Southwick SM, Charney DS. The neurobiology of posttraumatic stress disorder: An integration of animal and human research. In: Bremner JD, Saigh PA, editors. Posttraumatic Stress Disorder: A Comprehensive Text. Allyn and Bacon; Boston, MA: 1999. pp. 103–143.

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