Review
doi: 10.1016/0968-0004(91)90043-u.
Nuclear gadgets in mitochondrial DNA replication and transcription
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- PMID: 2057998
- DOI: 10.1016/0968-0004(91)90043-u
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Review
Nuclear gadgets in mitochondrial DNA replication and transcription
Trends Biochem Sci.
1991 Mar.
Abstract
In mammalian mitochondrial DNA, activation of the light-strand promoter mediates both priming of leading-strand replication and initiation of light-strand transcription. Accurate and efficient transcription requires at least two proteins: mitochondrial RNA polymerase and a separable transcription factor that can function across species boundaries. Subsequently, primer RNAs are cleaved by a site-specific ribonucleoprotein endoribonuclease that recognizes short, highly conserved sequence elements in the RNA substrate.
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