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. 2010 Jul 16;584(14):3233-8.
doi: 10.1016/j.febslet.2010.06.020. Epub 2010 Jun 19.

Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis

Toshihiro Inoue  1 , Tetsushi Kagawa, Miyuki Inoue-Mochita, Kyoichi Isono, Naoki Ohtsu, Ikuo Nobuhisa, Mikiko Fukushima, Hidenobu Tanihara, Tetsuya Taga
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Free article

Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis

Toshihiro Inoue et al. FEBS Lett. .
Free article

Abstract

Members of the homeodomain-interacting protein kinase (HIPK) family are involved in various intracellular regulatory mechanisms. The present study focused on clarifying the functions of HIPK family members in ocular organization during late embryogenesis. HIPK1 and HIPK2 were expressed in the inner retina during late embryogenesis. Hipk1(+/-)Hipk2(-/-) mice had a greater frequency of small eyes with a lens deficiency and abnormally laminated and thickened retinas than did wild-type littermates. These data indicate that Hipk1 and Hipk2 are involved in regulation of eye size, lens formation and retinal lamination during late embryogenesis.

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