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. 2010 Sep;192(17):4526-7.
doi: 10.1128/JB.00596-10. Epub 2010 Jun 25.

Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis

Xiang-Jing Wang  1 , Yi-Jun Yan, Bo Zhang, Jing An, Ji-Jia Wang, Jun Tian, Ling Jiang, Yi-Hua Chen, Sheng-Xiong Huang, Min Yin, Ji Zhang, Ai-Li Gao, Chong-Xi Liu, Zhao-Xiang Zhu, Wen-Sheng Xiang
Affiliations

Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis

Xiang-Jing Wang et al. J Bacteriol. 2010 Sep.

Abstract

Streptomyces bingchenggensis is a soil-dwelling bacterium producing the commercially important anthelmintic macrolide milbemycins. Besides milbemycins, the insecticidal polyether antibiotic nanchangmycin and some other antibiotics have also been isolated from this strain. Here we report the complete genome sequence of S. bingchenggensis. The availability of the genome sequence of S. bingchenggensis should enable us to understand the biosynthesis of these structurally intricate antibiotics better and facilitate rational improvement of this strain to increase their titers.

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