Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Oct;68(4):298-302.
doi: 10.1203/PDR.0b013e3181ed1864.

Ibuprofen treatment for closure of patent ductus arteriosus is not associated with increased risk of neuropathology

Michelle Loeliger  1 , Amy Shields, Donald McCurnin, Ronald I Clyman, Bradley Yoder, Terrie E Inder, Sandra M Rees
Affiliations

Ibuprofen treatment for closure of patent ductus arteriosus is not associated with increased risk of neuropathology

Michelle Loeliger et al. Pediatr Res. 2010 Oct.

Abstract

Ibuprofen is an effective pharmacological intervention for closure of a patent ductus arteriosus (PDA) in preterm infants and is an alternative to surgical ligation; however, it is not certain whether ibuprofen treatment is associated with adverse effects on the brain. Therefore, this study examined neuropathological outcomes of ibuprofen therapy for a PDA. Fetal baboons were delivered at 125 d of gestation (dg; term ∼185 dg) by caesarean section, given surfactant, and ventilated for 14 d with positive pressure ventilation (PPV). Baboons were randomly allocated to receive either ibuprofen (PPV+ ibuprofen, n = 8) or no therapy (PPV, n = 5). Animals were killed on day 14 and brains assessed for cerebral growth, development, and neuropathology. Body and brain weights, the total volume of the brain, and the surface folding index (measure of brain growth) were not different (p > 0.05) between PPV+ ibuprofen-treated and PPV animals. There was no difference (p > 0.05) in the number of myelin basic protein-immunoreactive (IR) oligodendrocytes, glial fibrillary acid protein-IR astrocytes, or Iba1-IR macrophages/microglia in the forebrain. No overt cerebellar alterations were observed in either group. Ibuprofen treatment for PDA closure in the preterm baboon neonate is not associated with any increased risk of neuropathology or alterations to brain growth and development.

PubMed Disclaimer

Figures

Figure 1
Figure 1
A, B: There was no difference in the areal density of GFAP-IR astrocyte in the deep white matter (WM) between PPV (A) and PPV+ ibuprofen (B) animals; arrows indicate astrocytes. C, D: the areal density of MBP-IR oligodendrocytes in cerebral WM was not different between PPV (C) and PPV+ ibuprofen (D) animals; arrows indicate myelinated fibers. E, F: The areal density of Iba-IR macrophages/microglia (arrows) in the cerebral WM was not different between PPV (E) and PPV+ ibuprofen (F) animals. Scale bars A-F=100μm; WM, white matter.
See this image and copyright information in PMC

References

    1. Bodeau-Livinec F, Marlow N, Ancel PY, Kurinczuk JJ, Costeloe K, Kaminski M. Impact of intensive care practices on short-term and long-term outcomes for extremely preterm infants: comparison between the British Isles and France. Pediatrics. 2008;122:e1014–e1021. - PubMed
    1. Marlow N, Wolke D, Bracewell MA, Samara M. Neurologic and developmental disability at six years of age after extremely preterm birth. N Engl J Med. 2005;352:9–19. - PubMed
    1. Marlow N, Hennessy EM, Bracewell MA, Wolke D. Motor and executive function at 6 years of age after extremely preterm birth. Pediatrics. 2007;120:793–804. - PubMed
    1. Clyman RI. Mechanisms regulating the ductus arteriosus. Biol Neonate. 2006;89:330–335. - PubMed
    1. Chorne N, Leonard C, Piecuch R, Clyman RI. Patent ductus arteriosus and its treatment as risk factors for neonatal and neurodevelopmental morbidity. Pediatrics. 2007;119:1165–1174. - PubMed

Publication types

MeSH terms