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. 2010 Jul;42(7):558-60.
doi: 10.1038/ng0710-558.

Hints of hidden heritability in GWAS

Greg Gibson

Hints of hidden heritability in GWAS

Greg Gibson. Nat Genet. 2010 Jul.

Abstract

Although susceptibility loci identified through genome-wide association studies (GWAS) typically explain only a small proportion of the heritability, a classical quantitative genetic analysis now argues that considering together all common SNPs can explain a large proportion of the heritability of these complex traits. A related study provides recommendations for the sample sizes needed in future GWAS to identify additional susceptibility loci.

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References

    1. Nat Genet. 2010 Jul;42(7):570-5 - PubMed
    1. Nat Rev Genet. 2010 Jun;11(6):446-50 - PubMed
    1. PLoS Genet. 2010 Feb 26;6(2):e1000864 - PubMed
    1. Nature. 2009 Aug 6;460(7256):748-52 - PubMed
    1. Trends Genet. 2008 Dec;24(12):595-603 - PubMed

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