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. 2010 Jan;72(1):1-11.
doi: 10.4103/0250-474X.62228.

Exenatide: a new promising antidiabetic agent

C K Chakraborti  1
Affiliations

Exenatide: a new promising antidiabetic agent

C K Chakraborti. Indian J Pharm Sci. 2010 Jan.

Abstract

Exenatide is a unique agent which can effectively control blood glucose levels in type 2 diabetes mellitus without producing dangerous adverse effects. In addition, it can lower body weight which is very essential for the treatment of obese type 2 diabetes mellitus patients. Since it can delay the destruction of islet beta-cells, type 2 diabetes mellitus patients are not rapidly converted to type 1 diabetes mellitus and ultimately appearance of complications of the disease is halted or delayed. Its long-acting-release formula, which would be used once per week, simultaneously retaining all the properties of twice-daily subcutaneous administration, is undergoing clinical trial. This drug is considered as an adjunct to metformin/sulfonylureas/insulin.

Keywords: Exenatide; exendin-4; glucagon-like peptide-1; glycosylated hemoglobin; type 2 diabetes mellitus.

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Figures

Fig. 1
Fig. 1
The amino acid sequences of (A) GLP-1 and (B) Exendin-4
See this image and copyright information in PMC

References

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