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Review
. 2010;13(5):385-410.
doi: 10.1080/10937401003673750.

Transport of inorganic mercury and methylmercury in target tissues and organs

Christy C Bridges  1 , Rudolfs K Zalups
Affiliations
Review

Transport of inorganic mercury and methylmercury in target tissues and organs

Christy C Bridges et al. J Toxicol Environ Health B Crit Rev. 2010.

Abstract

Owing to the prevalence of mercury in the environment, the risk of human exposure to this toxic metal continues to increase. Following exposure to mercury, this metal accumulates in numerous organs, including brain, intestine, kidneys, liver, and placenta. Although a number of mechanisms for the transport of mercuric ions into target organs were proposed in recent years, these mechanisms have not been characterized completely. This review summarizes the current literature related to the transport of inorganic and organic forms of mercury in various tissues and organs. This review identifies known mechanisms of mercury transport and provides information on additional mechanisms that may potentially play a role in the transport of mercuric ions into target cells.

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References

    1. Adam KR 1951. The effects of dithiols on the distribution of mercury in rabbits. Br. J. Pharmacol. Chemother 6:483–491. - PMC - PubMed
    1. Afonso JF and De Alvarez RR 1960. Effects of mercury on human gestation. Am. J. Obstet. Gynecol 80:145–154. - PubMed
    1. Akerboom TP, Narayanaswami V, Kunst M, and Sies H 1991. ATP-dependent S-2,4-dinitrophenylglutathione transport in canalicular plasma membrane vesicles from rat liver. J. Biol. Chem 266:13147–13152. - PubMed
    1. Alexander J, and Aaseth J 1982. Organ distribution and cellular uptake of methyl mercury in the rat as influenced by the intra-and extracellular glutathione concentration. Biochem. Pharmacol 31:685–690. - PubMed
    1. Amin-Zaki L, Elhassani S, Majeed MA, Clarkson TW, Doherty RA, and Greenwood M 1974. Intra-uterine methylmercury poisoning in Iraq. Pediatrics 54:587–595. - PubMed

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