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. 2010 Oct 5;153B(7):1347-9.
doi: 10.1002/ajmg.b.31108.

Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder

Elaine K Green  1 , Detelina Grozeva, Valentina Moskvina, Marian L Hamshere, Ian R Jones, Lisa Jones, Liz Forty, Sian Caesar, Katherine Gordon-Smith, Christine Fraser, Ellie Russell, David St Clair, Allan H Young, Nicol Ferrier, Anne Farmer, Peter McGuffin, Peter A Holmans, Michael J Owen, Michael C O'Donovan, Nick Craddock
Affiliations

Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder

Elaine K Green et al. Am J Med Genet B Neuropsychiatr Genet. .

Abstract

We have previously reported evidence that variation at GABA(A) receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052).

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