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. 2010 Jul;136(1):21-7.
doi: 10.1085/jgp.201010471.

Regulation of contraction in mammalian striated muscles--the plot thick-ens

Richard L Moss  1 , Daniel P Fitzsimons
Affiliations

Regulation of contraction in mammalian striated muscles--the plot thick-ens

Richard L Moss et al. J Gen Physiol. 2010 Jul.
No abstract available

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Figures

Figure 1.
Figure 1.
Diagram showing proposed effects of cMyBP-C on the cross-bridge interaction cycle in cardiac muscle. Based on Campbell's (1997) model, strongly bound cross-bridges (predominantly A-M · ADP) cooperatively recruit cross-bridges to bind to the thin filament (represented by A). We propose that cMyBP-C is normally repressive to this mechanism by constraining cross-bridges. However, this constraint is relieved by ablation or PKA phosphorylation of cMyBP-C, resulting in increased cooperative recruitment and rates of recruitment of cross-bridges. As shown in the diagram, Ca2+ is required for activation of contraction (+Ca2+), but once initiated, the feedback mechanism shown here cooperatively increases the numbers and rate of cross-bridge binding to actin.
See this image and copyright information in PMC

References

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    1. Campbell K. 1997. Rate constant of muscle force redevelopment reflects cooperative activation as well as cross-bridge kinetics. Biophys. J. 72:254–262 10.1016/S0006-3495(97)78664-8 - DOI - PMC - PubMed
    1. Colson B.A., Bekyarova T., Fitzsimons D.P., Irving T.C., Moss R.L. 2007. Radial displacement of myosin cross-bridges in mouse myocardium due to ablation of myosin binding protein-C. J. Mol. Biol. 367:36–41 10.1016/j.jmb.2006.12.063 - DOI - PMC - PubMed
    1. Colson B.A., Bekyarova T., Locher M.R., Fitzsimons D.P., Irving T.C., Moss R.L. 2008. Protein kinase A-mediated phosphorylation of cMyBP-C increases proximity of myosin heads to actin in resting myocardium. Circ. Res. 103:244–251 10.1161/CIRCRESAHA.108.178996 - DOI - PMC - PubMed
    1. Colson B.A., Locher M.R., Bekyarova T., Patel J.R., Fitzsimons D.P., Irving T.C., Moss R.L. 2010. Differential roles of regulatory light chain and myosin binding protein-C phosphorylations in the modulation of cardiac force development. J. Physiol. 588:981–993 10.1113/jphysiol.2009.183897 - DOI - PMC - PubMed

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