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Case Reports
. 2009:2009:393452.
doi: 10.1155/2009/393452. Epub 2009 Nov 4.

Folgoration as an Example of Pathergy in a Patient Affected by Pyoderma Gangrenosum and Takayasu's Arteritis

A G Richetta  1 , S D'Epiro, C Mattozzi, S Giancristoforo, S Calvieri
Affiliations
Case Reports

Folgoration as an Example of Pathergy in a Patient Affected by Pyoderma Gangrenosum and Takayasu's Arteritis

A G Richetta et al. Dermatol Res Pract. 2009.

Abstract

Pyoderma gangrenosum (PG) is a neutrophilic dermatosis of unknown aetiology. Clinical manifestations of PG are characterized by destructive, necrotizing, and noninfective ulceration of the skin. 20-30% of cases are initiated and aggravated by minor trauma or surgery, a phenomenon named pathergy. PG is related to several autoimmune diseases including ulcerative colitis, Crohn's disease, rheumatoid arthritis, and monoclonal gammopathy. The association with Takayasu's arteritis (TA), a chronic inflammatory and stenotic disease of large and medium-sized arteries, is instead less common. We report a case of PG associated with TA that was induced by an accident with folgoration of the skin; in this case the folgoration can be considered as an exemple of Pathergy, that is, a characteristic feature of PG.

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Figures

Figure 1
Figure 1
Esulcerative lesions on the legs, with unruffled limits and violaceus borders.
Figure 2
Figure 2
Pustules gradually involving in esulcerative lesions, characterized by a progressive external expansion, unruffled limits and violaceus borders.
Figure 3
Figure 3
The complete resolution of the skin lesions after one month of therapy.
See this image and copyright information in PMC

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