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. 2010 Jun 24;6(6):e1000881.
doi: 10.1371/journal.ppat.1000881.

Entry and fusion of emerging paramyxoviruses

Rebecca Ellis Dutch  1
Affiliations

Entry and fusion of emerging paramyxoviruses

Rebecca Ellis Dutch. PLoS Pathog. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author has declared that no competing interests exist.

Figures

Figure 1
Figure 1. A phylogenetic tree of the paramyxovirus family, built using fusion protein sequence comparison.
The tree was generated from a PROMALS multiple sequence alignment using PROTDIST and FITCH from the PHYLIP 3.65 software package and displayed using HYPERTREE 1.0.0. CDV, canine distemper virus; HMPV, human metapneumovirus; HPIV3, human parainfluenza virus 3; HRSV, human respiratory syncytial virus; NDV, Newcastle disease virus; PIV5, parainfluenza virus 5.
Figure 2
Figure 2. Proteolytic processing of the henipavirus fusion proteins.
(A) Schematic of F protein cleavage/activation. FP, fusion peptide; HR1 and HR2, heptad repeat; S-S, disulfide bond; TM, transmembrane domain. (B) Model for proteolytic processing of the henipavirus F proteins. The Hendra or Nipah F proteins are synthesized in the endoplasmic reticulum (ER), transit through the secretory pathway to the plasma membrane (PM), and are subsequently endocytosed. Following interaction with cathepsin L at an undetermined point in the endocytic pathway, the cleaved protein is recycled to the plasma membrane.
See this image and copyright information in PMC

References

    1. Lamb RA, Parks GD. Knipe DM, Howley PM, editors. Paramyxoviridae: the viruses and their replication. Fields Virology: Lippincott, Williams and Wilkins. 2007. pp. 1449–1496.
    1. Eaton BT, Broder CC, Middleton D, Wang LF. Hendra and Nipah viruses: different and dangerous. Nat Rev Microbiol. 2006;4:23–35. - PMC - PubMed
    1. Eaton BT, Mackenzie JS, Wang L-F. Knipe DM, Howley PM, editors. Henipaviruses. Fields Virology: Lippincott, Williams and Wilkins. 2007. pp. 1587–1600.
    1. van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, et al. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001;7:719–724. - PMC - PubMed
    1. Collins PL, Crowe JE. Knipe DM, Howley PM, editors. Respiratory syncytial virus and metapneumovirus. Fields Virology: Lippincott, Williams and Wilkins. 2007. pp. 1601–1646.

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