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. 2010 Oct;248(10):1487-91.
doi: 10.1007/s00417-010-1434-6. Epub 2010 Jun 29.

Rubella virus as a possible etiological agent of Fuchs heterochromic iridocyclitis

Jun Suzuki  1 , Hiroshi Goto, Katsuhiro Komase, Hitoshi Abo, Kaoru Fujii, Noriyuki Otsuki, Kiyoko Okamoto
Affiliations

Rubella virus as a possible etiological agent of Fuchs heterochromic iridocyclitis

Jun Suzuki et al. Graefes Arch Clin Exp Ophthalmol. 2010 Oct.

Abstract

Background: To determine whether rubella virus is involved in the pathogenesis of Fuchs heterochromic iridocyclitis (FHI).

Methods: Fourteen patients (14 eyes) diagnosed with FHI based on characteristic ocular manifestations and eight control subjects were studied. Aqueous humor (AH) samples from 14 FHI patients and one vitreous sample from a FHI patient were analyzed for intraocular antibody production against rubella virus by calculation of the Goldmann-Witmer coefficient (GWC). Viral detection by nested polymerase chain reaction and isolation by culture in RK-13 cells were conducted in nine FHI patients. In addition to laboratory examinations, medical history of rubella virus vaccination was also obtained.

Results: Ten patients with FHI examined showed intraocular synthesis of rubella virus antibodies (GWC > 3). A high index of rubella virus antibody production was also found in the vitreous sample (GWC = 30.6). GWC in all control subjects were below detectable level. The rubella genome was detected in two of nine patients, and rubella virus was isolated from one of nine patients with FHI. None of the patients with FHI had been vaccinated against rubella.

Conclusions: Our laboratory data strongly suggest a relationship between FHI and rubella virus.

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References

    1. Surv Ophthalmol. 2008 Mar-Apr;53(2):95-111 - PubMed
    1. Graefes Arch Clin Exp Ophthalmol. 2010 Apr;248(4):565-71 - PubMed
    1. Invest Ophthalmol Vis Sci. 1989 Mar;30(3):443-8 - PubMed
    1. Am J Ophthalmol. 2007 Sep;144(3):424-428 - PubMed
    1. Curr Opin Ophthalmol. 2005 Dec;16(6):356-63 - PubMed

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